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Browse Recruiting Trials |
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 With help from the ALS Association, NEALS provides up-to-date
information for finding both federally and privately funded clinical studies focusing on ALS and motor neuron diseases. You can locate both
interventional trials, which examine if treatments are effective and safe under controlled environments, and observation trials, which examine people
in more natural environments.
NEALS sources this database from public information posted on clinicaltrials.gov and other
public websites. This feature is updated regularly, so please check back. If you need support please contact our ALS Trial Expert.
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Phase III Interventional Trials in ALS:
Phase II Interventional Trials in ALS:
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Trial Name |
Study Status |
Disease Categories |
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| 1. |
 Trial of High fat/High Calorie Diet versus Optimal Nutrition in Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 2. |
Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Familial ALS |
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| 3. |
A Phase I/II, Open Label Study to Evaluate Safety, Tolerability and Therapeutic Effects of Transplantation of Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in ALS Patients |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS |
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| 4. |
Randomized Double Blind Placebo Controlled Cross-Over Study of Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease and ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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Other Interventional Trials:
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Trial Name |
Study Status |
Disease Categories |
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| 1. |
A Phase I, Open-label, First-in-human Feasibility and Safety Study of Human Spinal Cord derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 2. |
Effect of Noninvasive Positive Pressure Ventilation on Pulmonary Function Testing in Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 3. |
Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Aclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 4. |
Phase I/II Study of SOD1 Inhibition by Pyrimethamine in Familial ALS |
Active, currently recruiting |
Familial ALS |
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| 5. |
A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 6. |
A Randomized Crossover Study of Standard, Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in Amyotrophic Lateral Sclerosis (ALS) Patients |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 7. |
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP) |
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| 8. |
Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-Life |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer with a Family History of ALS, Other: Assessment of Care |
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| 9. |
A Single-Center, Randomized, Blinded, Placebo- and Active-Controlled Crossover Study to Evaluate the Effect of Dexpramipexole (BIIB050) on the QTc Interval in Healthy Volunteers |
Active, currently recruiting |
Healthy Volunteer |
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| 10. |
Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 11. |
Coping Effectiveness Training for Recently Diagnosed ALS Patients and Care Partners |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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Observational Studies:
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Trial Name |
Study Status |
Disease Categories |
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| 1. |
Pre-familial Amyotrophic Lateral Sclerosis (Pre-fALS) study |
Active, currently recruiting |
Healthy Volunteer with a Family History of ALS |
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| 2. |
Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 3. |
Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer with a Family History of ALS |
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| 4. |
Non-Invasive Measurement of GI Motility in Patients With ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Healthy Volunteer |
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| 5. |
Familial Amyotrophic Lateral Sclerosis (FALS) Study |
Active, currently recruiting |
Healthy Volunteer with a Family History of ALS |
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| 6. |
ALS Tissue Donation Program |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS |
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| 7. |
Quantitative Measurement of Nutritional Substrate Utilization in Patients With ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer |
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| 8. |
EEG-Based Brain-Computer Interface Project for Individuals With ALS |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer |
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| 9. |
Satisfaction Survey for ALS Patients Comparing Rooms With and Without Assistive Technology |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 10. |
Assessment of the Cyberlink Control System for Use by the ALS Patient |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 11. |
Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient Population |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 12. |
Family Studies in Neuromuscular Disorders |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer, Healthy Volunteer with a Family History of ALS |
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| 13. |
PRISM Registry: Pseudobulbar Affect Registry Series |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 14. |
Oxidative Stress in Motor Neuron Disease: COSMOS-PLS Add-On Study |
Active, currently recruiting |
Primary Lateral Sclerosis (PLS) |
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| 15. |
Collection of Blood Samples for DNA Analysis in Motor Neuron Diseases |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS) |
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| 16. |
Discovery and Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) (BIO_ALS-02) |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS |
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| 17. |
Clinical and Molecular Manifestations of Inherited Neurological Disorders |
Active, currently recruiting |
Familial ALS |
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| 18. |
UW/VA Madison Brain Bank |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS |
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| 19. |
Magnetic Resonance Spectroscopy in Amyotrophic Lateral Sclerosis |
Active, currently recruiting |
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer |
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| 20. |
Screening and Natural History: Primary Lateral Sclerosis and Related Disorders |
Active, currently recruiting |
Primary Lateral Sclerosis (PLS) |
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